INTERDISCIPLINARY RESEARCH COLLABORATION
Understanding membrane permeability
and efflux in antimicrobial resistance
BARRIER brings together expertise in microbiology, bioinformatics, metabolomics and mathematical modelling across four research institutes to uncover how bacterial membrane permeability and efflux influence antimicrobial resistance.
About BARRIER
BARRIER is an interdisciplinary research collaboration bringing together microbiology, bioinformatics, metabolomics and mathematical modelling to understand bacterial membrane permeability and efflux in antimicrobial resistance.
By combining experimental and computational approaches across four leading research institutes, we aim to uncover fundamental mechanisms of antimicrobial resistance and accelerate the development of new therapeutic strategies.
Our Research
Our interdisciplinary approach combines experimental biology with computational science to understand antimicrobial resistance across multiple scales.
Microbiology
Investigating bacterial membrane permeability and efflux mechanisms through experimental microbiology.
Bioinformatics
Analysing biological datasets using TraDIS to identify mechanisms underpinning antimicrobial resistance.
Metabolomics
Characterising bacterial metabolism and physiological responses to various antimicrobial stress.
Mathematical Modelling
Developing mathematical models to predict antimicrobial transport within bacteria and resistance.
Leadership Team
BARRIER is led by six principal investigators whose complementary expertise spans microbiology, bioinformatics, metabolomics and mathematical modelling across four leading UK research institutions.
Professor Timothy Overton
University of Birmingham
Microbial Biotechnology
Professor Sara Jabbari
University of Birmingham
Mathematical Biology
Dr Andrew Edwards
Imperial College London
Molecular Microbiology
Dr Dong-Hyun Kim
University of Nottingham
Analytical Bioscience
Professor Mark Webber
Quadrum Institute
Antimicrobial Resistance Evolution